HOW IT IS THOUGHT TO WORK

TRODELVY IS DESIGNED TO WORK DIFFERENTLY THAN TRADITIONAL CHEMOTHERAPIES

Diagram showing the different molecular parts of TRODELVYᵀᴹ
What TRODELVY is made of

Trodelvy is a type of drug called an antibody-drug conjugate, or ADC for short. Unlike traditional chemotherapy, ADCs contain 3 parts: an antibody, an anti-cancer drug, and a linker.

A Antibody

Looks for a specific protein, in this case Trop-2, which is found to be overexpressed in many cancers, including bladder cancer

B Anti-cancer drug

Kills cancer cells once they’re found

C Linker

Connects the anti-cancer drug to the antibody

HOW TRODELVY IS THOUGHT TO ATTACK BLADDER CANCER TUMORS

Scientists discovered that patients with bladder cancer have tumor cells that more often contain the Trop-2 protein. TRODELVY binds to cells with Trop-2.

Information from laboratory studies suggest that this is how TRODELVY works. The clinical benefit of these observations is unknown.

Image showing TRODELVYᵀᴹ attaching to the TROP-2 protein on cancer cells
1. Attaches

The antibody in TRODELVY finds and sticks to the Trop-2 protein

Image showing TRODELVYᵀᴹ penetrating cancer cell
2. Penetrates

Once attached, TRODELVY delivers an anti-cancer drug directly into the bladder cancer cells

Image showing TRODELVYᵀᴹ destroying cancer cell
3. Destroys

TRODELVY kills the bladder cancer cells from within.

Trodelvy is the first ADVANCED BLADDER CANCER TREATMENT
to target THE Trop-2 PROTEIN