TRODELVY® (sacituzumab govitecan-hziy) is a prescription medicine used to treat adults with hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer that has spread to other parts of the body (metastatic) or cannot be removed by surgery, and who previously received endocrine therapy and at least two additional treatments for metastatic disease. It is not known if TRODELVY is safe and effective in people with moderate or severe liver problems or in children.
Real patient stories with TRODELVY
Ambassadors featured are compensated by Gilead.
This page features people being treated with TRODELVY at the time of the interview. These experiences may have changed since, and your experience may be different.
WHAT IS TRODELVY?
TRODELVY® (sacituzumab govitecan-hziy) is a prescription medicine used to treat adults with:
- triple-negative breast cancer (negative for estrogen and progesterone hormone receptors and HER2) that has spread to other parts of the body (metastatic) or cannot be removed by surgery, and who have received two or more prior treatments, including at least one treatment for metastatic disease.
- hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer that has spread to other parts of the body or cannot be removed by surgery, and who previously received endocrine therapy and at least two additional treatments for metastatic disease.
It is not known if TRODELVY is safe and effective in people with moderate or severe liver problems or in children.
About TRODELVY
Medicine is hard, but I feel like it's worth it based on my experience.
JanaLiving with mTNBC
Results may vary from person to person and maybe some weeks aren't as good as others. Side effects are different for everyone.
JacquieLiving with mTNBC
One common side effect I've had is nausea. My healthcare team was able to change around my medications for nausea until they found something that worked for me.
TanyaLiving with mTNBC
If you’re nervous about starting TRODELVY, self-educate and talk to your doctor. I think knowledge helps to turn down the volume on fear. If I victimize myself, I’m going to allow the fear to run the show.
KarenLiving with mTNBC
My healthcare provider gave me information on TRODELVY. She said it would be a good option for me at the time when she started me on it.
LisaLiving with mTNBC
Decision-making
You have to be your own best advocate, and you have to have a healthcare provider that is going to work with you and listen to your concerns.
JanaLiving with mTNBC
For me, it was a bit of blind faith. But that blind faith pulled me forward. My oncologist said that we were gonna try something else and I didn’t even think about it for a minute. I was just willing to be present for the possibility.
KarenLiving with mTNBC
I educate myself to be aware. I don’t crawl the web and look for all the answers. Rabbit holes can be dangerous. I just go to my source, which is my oncologist. That helps keep me in my reality, away from wishful thinking.
KarenLiving with mTNBC
You just have to open up to your doctors and let them know how you’re feeling, and they’re going to try and do what they can for you.
LisaLiving with mTNBC
I have a really good relationship with my healthcare provider. I put the decision in her hands and said, ‘just do what you need to do.’
LisaLiving with mTNBC
Feeling prepared
Tell your doctor if you have headaches, if you’re nauseous, whatever the case may be. If I didn’t have that discussion with the doctors and the nurses, how would they have known to adjust my plan?
JacquieLiving with mTNBC
Every one of us is different. Write down what you are feeling: pains, aches, everything. Bring that to your healthcare provider. They may be able to adjust things for you right there on-site. Little things like that may change the whole experience.
JacquieLiving with mTNBC
Before my treatment, I try to drink as much fluid as I can. I also start taking my anti-nausea medication my healthcare team prescribed. I make sure I’m eating healthy foods. Before my treatment, I put some cream on my port to make it more comfortable.
TanyaLiving with mTNBC
Motivation
I always have someone go with me. I’ve realized that if I go alone I tend not to have as good of an experience. I think the distraction helps a lot.
KatherineLiving with HR+/HER2- mBC
I don’t wear cancer as a badge of honor, and I don’t wear it as a badge of disgrace. It’s just part of my fabric.
JacquieLiving with mTNBC
I’m trying to focus most of my energy right now on the importance of acknowledging and giving gratitude to people in my life who are making or have made a huge impact on me or who are helping me.
JacquieLiving with mTNBC
Try to continue to be strong. I did it. You can do it.
LisaLiving with mTNBC
I feel like every day is a bonus day. That motivates me to live life more fully while I have it. I try to live in that day and focus on the things I can control instead of what I can’t control.
KarenLiving with mTNBC
My family is by my side. That’s what I need. They’re my strength. They’re my rock.
LisaLiving with mTNBC
Ambassadors featured are compensated by Gilead.
This page features people being treated with TRODELVY at the time of the interview. These experiences may have changed since, and your experience may be different.
TRODELVY® (sacituzumab govitecan-hziy) is a prescription medicine used to treat adults with hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer that has spread to other parts of the body (metastatic) or cannot be removed by surgery, and who previously received endocrine therapy and at least two additional treatments for metastatic disease.
It is not known if TRODELVY is safe and effective in people with moderate or severe liver problems or in children.
Important Safety Information
TRODELVY can cause serious side effects, including low white blood cell count and diarrhea:
Tap for Important Safety Information. TRODELVY can cause serious side effects, including low white blood cell count and diarrhea:
- Low white blood cell count (neutropenia) which is common and can sometimes be severe and lead to infections that can be life-threatening or cause death. Your healthcare provider should check your blood cell counts during treatment. If your white blood cell count is too low, your healthcare provider may need to lower your dose, give you a medicine to help prevent low blood cell count with future doses of TRODELVY, or in some cases may stop TRODELVY. Your healthcare provider may need to give you antibiotic medicines if you develop fever while your white blood cell count is low. Call your healthcare provider right away if you develop any of the following signs of infection: fever, chills, cough, shortness of breath, or burning or pain when you urinate.
- Severe diarrhea. Diarrhea is common and can be severe. Severe diarrhea can lead to loss of too much body fluid (dehydration) and kidney problems. Your healthcare provider should monitor you for diarrhea and give you medicine as needed to help control it. If you lose too much body fluid, your healthcare provider may need to give you fluids and electrolytes to replace body salts. If you develop diarrhea during your treatment with TRODELVY, your healthcare provider should check to see if it may be caused by an infection. Your healthcare provider may decrease your dose or stop TRODELVY if your diarrhea is severe and cannot be controlled with anti-diarrheal medicines.
- Call your healthcare provider right away the first time that you get diarrhea during treatment with TRODELVY; if you have black or bloody stools; if you have symptoms of dehydration, such as lightheadedness, dizziness, or faintness; if you are unable to take fluids by mouth due to nausea or vomiting; or if you are not able to get your diarrhea under control within 24 hours.
Do not receive TRODELVY if you have had a severe allergic reaction to TRODELVY. Ask your healthcare provider if you are not sure.
Allergic and infusion-related reactions which can be serious and life-threatening. Tell your healthcare provider or nurse right away if you get any of the following symptoms during your infusion of TRODELVY or within 24 hours after: swelling of your face, lips, tongue, or throat; hives; skin rash, itching, or flushing of your skin; fever; difficulty breathing or wheezing; lightheadedness, dizziness, feeling faint, or pass out; or chills or shaking chills (rigors).
Nausea and vomiting are common with TRODELVY and can sometimes be severe. Before each dose of TRODELVY, you will receive medicines to help prevent nausea and vomiting along with medicines to take home with instructions about how to take them. Call your healthcare provider right away if you have nausea or vomiting that is not controlled with the medicines prescribed for you. Your healthcare provider may decide to decrease your dose or stop TRODELVY if your nausea and vomiting is severe and cannot be controlled with anti-nausea medicines.
Before receiving TRODELVY, tell your healthcare provider about all of your medical conditions, including if you:
- have been told that you carry a gene for UGT1A1*28, which can increase your risk of getting side effects with TRODELVY, especially low white blood cell counts, with or without a fever, and low red blood cell counts.
- have liver problems.
- are pregnant or plan to become pregnant. TRODELVY can harm your unborn baby. Your healthcare provider should check to see if you are pregnant before you start receiving TRODELVY. TRODELVY may cause fertility problems in females, which could affect your ability to have a baby. Talk to your healthcare provider if fertility is a concern for you.
- Females who can become pregnant should use effective birth control during treatment and for 6 months after your last dose of TRODELVY. Talk to your healthcare provider about birth control choices that may be right for you during this time. Tell your healthcare provider right away if you become pregnant during treatment with TRODELVY.
- Males with a female partner who can become pregnant should use effective birth control during treatment and for 3 months after your last dose of TRODELVY.
- are breastfeeding or plan to breastfeed. It is not known if TRODELVY passes into your breastmilk and can harm your baby. Do not breastfeed during treatment and for 1 month after your last dose of TRODELVY.
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Certain medicines may affect the way TRODELVY works.
The most common side effects of TRODELVY include decreased white blood cell (leukocyte and lymphocyte) and red blood cell counts, feeling tired or weak, hair loss, constipation, increased sugar levels in the blood, decreased protein levels (albumin) in the blood, decreased appetite, changes in kidney function test, increased levels of enzyme called alkaline phosphatase in the blood (test for liver or bone problems), and decreased levels of magnesium, potassium, and sodium in the blood.
These are not all of the possible side effects of TRODELVY. Call your doctor for medical advice about side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Please click to see Important Facts about TRODELVY, including Important Warning.